Transactivation by E6 could contribute to oncogenesis.

2003 FEB 3 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "The expression of human papillomavirus (HPV) E6 oncoprotein is causally linked to high-risk HPV-associated human cancers. We have recently isolated hADA3, the human homologue of yeast transcriptional co-activator yADA3, as a novel E6 target.

"Human ADA3 binds to the high-risk (cancer-associated) but not the low-risk HPV E6 proteins and to immortalization-competent but not to immortalization-defective HPV16 E6 mutants, suggesting a role for the perturbation of hADA3 function in E6-mediated oncogenesis.

"We demonstrate here that hADA3 directly binds to the retinoic …